知识与财富的链接
目的 研究指出空气污染是2型糖尿病的危险因素。本文采用Meta分析方法 评价发展中国家空气污染与2型糖尿病之间的联系。方法 使用计算机检索PubMed、EMBASE和Web of Science数据库内截至2022年03月31日发表的发展中国家空气污染与2型糖尿病患病率或发病率之间关系的研究论文。使用比值比(OR)来评估疗效,对纳入的研究进行Meta分析。结果 共纳入在发展中国家进行的8项横断面研究和8项队列研究。对8项PM2.5相关的研究进行的Meta分析显示,暴露于PM2.5使2型糖尿病患病率增加,相关性为1.12 (95%CI1.07,1.17)(P<0.001)。由于纳入文献数量有限,未能定量评价空气污染与2型糖尿病发病率之间的相关性。结论 在发展中国家,暴露于PM2.5会导致2型糖尿病患病率增加。糖尿病易感人群应该注意减少空气污染暴露。
ObjectiveIn recent years, many studies have reported that air pollution is a risk factor for type 2 diabetes mellitus (T2DM). The aim of this systematic review and meta-analysis is to summarize the evidence about the association between exposure to air pollution and T2DM in developing countries.MethodsThe databases, including PubMed, EMBASE and Web of Science, were systematically searched for studies published up to 31 March 2022. Studies about the association between air pollution and T2DM prevalence or incidence in developing countries were included. The odds ratio (OR) was used as effect estimate. We synthesized the included studies in the meta-analysis.ResultsWe included 8 cross-sectional studies and 8 cohort studies, all conducted in developing countries. Meta-analysis of 8 studies on PM2.5 (particulate matter ≤ 2.5 µm in diameter) showed that T2DM prevalence was significantly associated with PM2.5 exposure (OR=1. 12; 95% CI: 1.07, 1.17; P<0.001). The association between air pollutants and T2DM incidence was not estimated due to the limited relevant studies.ConclusionsThe exposure to PM2.5 would be positively associated with an increased prevalence of T2DM in developing countries. Some effective measures should be taken to reduce air pollutant exposure in people who are vulnerable to diabetes.