The connection between meridians and viscera and brain has been widely concerned in recent years. Previous studies have confirmed that acupuncture can significantly regulate heart function, and its mechanism of action is closely related to the regulation of the nervous system.The hypothalamic paraventricular nucleus (PVN) is an important nerve nucleus involved in the regulation of visceral function. Scholars have carried out a lot of research on the neural mechanism of acupuncture regulating heart function.This article explores the mechanism of PVN in the regulation of cardiac function by acupuncture from the aspects of acupuncture regulating PVN neuron activity, neurotransmitter release, reducing the expression of inflammatory cytokines in PVN, reducing stress response, and regulating autonomic nerve activity, in order to lay the foundation for further revealing the neural regulation mechanism of acupuncture effect.