Cancer-related fatigue （CRF） is distinguished as deficiency of yang qi in terms of the eight-principle syndrome differentiation, and as deficiency of the spleen and kidneys in terms of the zang-fu syndrome differentiation. The main pathological mechanisms are insufficient spleen qi and deficient kidney essence. Based on the characteristics of the hypothalamic-pituitary-adrenal （HPA） in the neuroendocrine system, with the theory of invigorating qi and warming yang as an entry point, this paper explores the mechanism of action of thunder-fire moxibustion in the intervention of CRF associated with immune checkpoint inhibitors （ICIs）. The aim is to establish a theoretical foundation of traditional Chinese medicine （TCM） for the treatment of CRF and to explore the TCM external treatment for CRF.