To comply with the trends of medical education reform and development, the con-struction and practice in this paper strengthens talents cultivation to face post competency in the future. Oriented by post competency, some reformatory measures, including promoting undergra-duate tutorial system, multi-integration of courses, problem-based learning, clinical skill train-ing, specialized social practice as well as humanistic education, have been taken and covered the whole process of undergraduate medical education. It effectively enhances the cultivating quality of medical talents, and realizes the continuous improvement of medical students’ post competency.