知识与财富的链接
目的 探讨肝硬化患者发生轻微型肝性脑病（MHE）的影响因素,研究乳果糖治疗MHE的效果。方法 选取2018年9月—2020年12月就诊于山东第一医科大学附属消化病医院的246例肝硬化患者。通过数字连接实试验-A(NCT-A)和数字符号试验（DST）对MHE进行筛查,分析发生MHE的危险因素,研究乳果糖对MHE的治疗效果。结果 血氨（P<0.001）、血清白蛋白（P=0.002）、凝血酶原时间（P<0.001）、血钙（P=0.005）、血钠（P<0.001）、腹水史（P=0.043）、上消化道出血史（P=0.002）是发生MHE的独立危险因素。乳果糖治疗MHE可改善病人NCT-A(t=2.363,P=0.020)、DST(t=2.369,P=0.020)测试结果。结论 临床上应密切监测与MHE发生相关的危险因素。一旦发生MHE,可应用乳果糖进行治疗。
Objective To explore the risk factors of mild hepatic encephalopathy (MHE) in patients with liver cirrhosis, and study the effect of lactulose on MHE. Methods A total of 246 patients with cirrhosis were selected in Digestive Diseases Hospital of Shandong First Medical University from September 2018 to December 2020. MHE was screened by the number connection test A (NCT-A) and digital symbol test (DST). Clinical data were analyzed to determine the risk factors of MHE and to study the therapeutic effect of lactulose. Results Blood ammonia (P<0.001), serum albumin (P=0.002), prothrombin time (P<0.001), serum calcium (P=0.005), serum sodium (P<0.001), ascites history (P=0.043) and upper gastrointestinal bleeding history (P=0.002) were independent risk factors for MHE. Lactulose treatment in MHE patients could improve the results of NCT-A (t=2.363, P=0.020) and DST (t=2.369, P=0.020). Conclusions The risk factors of MHE should be monitored closely. Once MHE occurs, the patients can be treated with lactulose.
