知识与财富的链接
椎间盘退变(IVDD)引起的下腰痛已成为影响人类健康的重要疾病,非手术治疗和手术治疗均无法阻止其进展,故从分子水平入手的靶向治疗已成为目前的研究热点。外泌体携载的基质金属蛋白酶(MMPs)与IVDD过程中细胞外基质(ECM)成分的紊乱密切相关,其中MMP-1、MMP-2、MMP-3、MMP-9及MMP-14过表达与IVDD的严重程度呈正相关,MMP-8、MMP-10及MMP-12也不同程度地参与了IVDD的发生发展,但具体机制尚不清楚。因此,深入研究MMP-8、MMP-10、MMP-12参与IVDD发生的机制,开发针对外泌体及MMP-1、MMP-2、MMP-3、MMP-9、MMP-14的靶向药物,对从分子水平治疗IVDD具有一定的潜在价值。本文总结近年来外泌体携载的MMPs参与IVDD过程的研究进展,以期为从分子水平治疗IVDD提供新的靶点和方向。
Low back pain caused by intervertebral disc degeneration (IVDD) has become an important disease affecting human health, the current conservative treatment and surgical treatment cannot prevent its progression. Therefore, targeted therapy starting from the molecular level has become a current research hotspot. The matrix metalloproteinases (MMPs) carried by exosomes are closely related to the disorder of extracellular matrix (ECM) components in the IVDD process, MMP-1, MMP-2,MMP-3, MMP-9, and MMP-14 overexpression is positively correlated with the severity of IVDD. MMP-8, MMP-10, and MMP-12 also participate in the occurrence and progression of IVDD to varying degrees, but the specific mechanism is still unclear. Therefore,in-depth study of the mechanism of MMP-8, MMP-10, MMP-12 involved in the occurrence of IVDD, and the development of targeted drugs for exosomes and MMP-1, MMP-2, MMP-3, MMP-9, MMP-14 have certain potential value to the molecular level treatment of IVDD. This article aims to summarize the recent research progress in the involvement of MMPs carried by exosomes in the process of IVDD, in order to provide new targets and directions for the treatment of IVDD at the molecular level.
