知识与财富的链接
目的 探讨双手腱鞘炎在RA中的诊断价值。 方法 对76例已确诊的RA患者进行双手超声检查,选取同时存在滑膜炎和腱鞘炎的RA患者45例为观察组,记录临床特点、实验室指标、DAS28、填写健康评估问卷（HAQ）,对超声指标（滑膜增生、滑膜炎、腱鞘炎、骨侵蚀）进行半定量分级。选取存在手部腱鞘炎的非RA患者42例为对照组。采用Mann-Whitney U检验,Spearman秩相关, U检验进行统计分析。 结果 ① RA组滑膜增生[7.50（3.00,17.50）]、滑膜炎[6.00（2.00,14.00）]、腱鞘炎[6.00（2.75,12.00）]、骨侵蚀[0.50（0.00,4.00）]与非RA组滑膜增生[5.00（3.00,6.00）]、滑膜炎[3.00（2.00,4.30）]、腱鞘炎[2.00（1.00,3.00）]、骨侵蚀[0.00（0.00,1.00）]相比差异均有统计学意义（ Z=2.143, P=0.032; Z=2.756, P=0.006; Z=5.560, P<0.01; Z=2.550, P=0.011）。② RA组滑膜增生、滑膜炎与肿胀关节数（SJC）、压痛关节数（TJC）、血小板计数、CRP、DAS28呈正相关[滑膜增生（ r=0.806, P<0.01; r=0.486, P<0.01; r=0.326, P<0.05; r=0.450, P<0.01; r=0.413, P<0.01）;滑膜炎（ r=0.819, P<0.01; r=0.446, P<0.01; r=0.351, P<0.05; r=0.481, P<0.01; r=0.412, P<0.01）]。腱鞘炎与SJC、CRP、DAS28呈正相关（ r=0.436, P<0.01; r=0.496, P<0.05; r=0.359, P<0.05）,骨侵蚀与病程、抗CCP抗体呈正相关（ r=0.418, P<0.01; r=0.338, P<0.05）。③滑膜增生、滑膜炎、腱鞘炎、骨侵蚀、滑膜炎联合腱鞘炎对RA诊断的敏感度分别为0.41,0.61,0.57,0.48,0.61,特异度分别为0.95,0.76,1,0.83,0.93。④腱鞘炎的受试者工作特征曲线（ROC）曲线下面积最大（AUC=0.841）,腱鞘炎、滑膜炎联合腱鞘炎的曲线下面积与滑膜增生、滑膜炎、骨侵蚀相比差异有统计学意义[腱鞘炎（ Z=3.291, P=0.001; Z=2.651, P=0.008; Z=3.032, Z=0.002）;滑膜炎联合腱鞘炎（ Z=4.346, P=0.001; Z=3.753, P=0.001; Z=2.547, P=0.012）]。 结论 滑膜炎对RA诊断敏感度高,腱鞘炎对RA诊断特异度高,滑膜炎联合腱鞘炎可以提高RA诊断特异度。
Objective To explore the diagnostic value of hand tenosynovitis in rheumatoid arthritis (RA). Methods Seventy-six RA patients were enrolled for hands ultrasound examination. Forty-five RA patients with synovitis and tenosynovitis were selected as the study group, clinical characteristics, laboratory test results, disease activity score for 28 joint counts (DAS28), were evaluated and assessed, and the health assessment questionnaire (HAQ) was filled out, and semi-quantitative classification the ultrasonic indicators (synovial hyperplasia, synovitis, tenosynovitis, bone erosion) were also assessed. Forty-two non-RA patients with hand tenosynovitis were selected as the control group. Mann-whitney U test, Spearman correlation and paired U test were used for statistical analysis. Results ① In the RA group, synovial hyperplasia [7.50(3.00, 17.50)], synovitis [6.00(2.00, 14.00)], tenosynovitis [6.00(2.00, 12.00)], bone erosion [0.50(0.00, 4.00)] were statisticantly different when compared with in non-RA group in hyperplasia [5.00(3.00, 6.00)], synovitis [3.00(2.00, 4.30)], tenosynovitis [2.00(1.00, 3.00)], bone erosion [0.00(0.00, 1.00)] ( Z=2.143, P=0.032; Z=2.756, P=0.006; Z=5.560, P<0.01; Z=2.550, P=0.011). ② In the RA group, synovial hyperplasia and synovitis were positively correlated with swollen joint counts (SJC), tender joint counts (TJC), platelet (PLT), C-reactive pro-tein (CRP) and DAS28 [synovial hyperplasia ( r=0.806, P<0.01; r=0.486, P<0.01; r=0.326, P<0.05; r=0.450, P<0.01; r=0.413, P<0.01); and synovitis ( r=0.819, P<0.01; r=0.446, P<0.01; r=0.351, P<0.05; r=0.481, P<0.01; r=0.412, P<0.01)]. Tenosynovitis was positively correlated with SJC, CRP and DAS28 ( r=0.436, P<0.01; r=0.496, P<0.05; r=0.359, P<0.05) , bone erosion was positively correlated with disease course and anti-cyclic citrullinated peptide (CCP) antibody ( r=0.418, P<0.01; r=0.338, P<0.05) . ③ The sensitivity of synovial hyperplasia, synovitis, tenosynovitis, bone erosion and synovitis combined with tenosynovitis for the diagnosis of RA was 0.41, 0.61, 0.57, 0.48, 0.61 and the specificity was 0.95, 0.76, 1, 0.83, 0.93, respectively. ④ The largest area under the ROC curve was tenosynovitis [area under the curve (AUC)=0.841], the area under the curve of tenosynovitis and synovitis combined with tenosynovitis was significantly different from synovitis hyperplasia, synovitis and bone erosion [tenosynovitis( Z=3.291, P=0.001; Z=2.651, P=0.008; Z=3.032, P=0.002); synovitis combined with tenosynovitis( Z=4.346, P=0.001; Z=3.753, P=0.001; Z=2.547, P=0.012)]. Conclusion Synovitis has a high sensitivity for the diagnosis of RA, and tenosynovitis has a high specificity for the diagnosis of RA, synovitis combined with tenosynovitis can improve the specificity for the diagnosis of RA.
