知识与财富的链接
本文报道1例67岁前列腺癌患者,在雄激素剥夺治疗和多西他赛治疗后迅速进展。该患者的母亲和父亲分别患有乳腺癌和肺癌。基因测序提示该患者存在BRCA2基因突变。患者的母亲和儿子同样存在BRCA2基因突变。患者接受卡铂化疗后肿瘤得到控制。铂类化疗可能是治疗BRCA2基因突变前列腺癌的有效治疗方案。
A 67-year-old patient diagnosed with prostate cancer who had rapid disease progression after androgen deprivation therapy and subsequent docetaxel treatment. His mother and father were diagnosed with breast cancer and lung cancer, respectively. Next generation sequencing demonstrated a novel pathogenic germline BRCA2 mutation of this patient. His mother and son were found to have the same BRCA2 mutation. The patient experienced impressive and durable responses to carboplatin treatment. Platinum chemotherapy may be an effective option for BRCA2-mutated prostate cancer.
