Objective To establish a method for the simultaneous determination of 26 kinds of veterinary drug residues in 3 categories including sulfonamide, quinolones and tetracyclines based on duck meat by ultra performance liquid chromatography-tandem triple quadrupole mass spectrometry. Methods The 0.1% formic acid acetonitrile extraction was used , QuEChERS purification agent was used to remove impurities. After nitrogen blowing in a 45 ℃ water bath to near dryness, the mixture was diluted with 0.1% formic acid water acetonitrile (1:1, V:V) and analyzed qualitatively and quantitatively using ultra performance liquid chromatography-tandem triple quadrupole mass spectrometry. Results The 26 kinds of veterinary drugs showed good linearity in the range of 2.0-300.0 ng/mL (r2>0.996), the limits of detection were 0.28 ~ 6.02 μg/kg, the limits of quantification were 11.28 ~ 15.03 μg/kg. The average recovery rates of 26 kinds of veterinary drugs at different concentration levels (5.0, 50, 300.0 μg/kg) were 75.08% ~ 112.35% (n=15), and the relative standard deviation (RSD) was 1.25% ~ 7.88% (n=15). Conclusion This method features simple pretreatment operations, high efficiency, and low consumption of reagents and materials. It is suitable for the preliminary screening and detection of 26 kinds of veterinary drug residues in 3 categories for large quantities of duck meat samples.