Under the background of new engineering and combined with higher engineering education, the practical teaching of virtual simulation courses is comprehensively reformed. The authors put forward the practical teaching concept based on big engineering perspective. In addition, the development needs of knowledge, ability and quality that innovative talents of higher engineering education should possess are guaranteed from the new construct, new teaching content, new cultivation mode and new evaluation method of practical innovation education. And guide the practice teaching to “active practice, the pursuit of innovation” change, then provide the theoretical basis and experience reference for further realizing the “whole process education” of engineering education.