知识与财富的链接
目的 探讨畲药食凉茶组方对痰湿内阻型阻塞性睡眠呼吸暂停低通气综合征（obstructive sleep apnea hypopnea syndrome,OSAHS）患者的临床疗效以及血清丙二醛（malondialdehyde,MDA）和晚期蛋白氧化产物（advanced oxidation protein products,AOPP）水平的影响。方法 选取2019年5月至2022年5月丽水市中医院收治的痰湿内阻型OSAHS患者60例,按照随机数字表法分为对照组和治疗组,每组各30例。对照组患者选用无创呼吸机予以持续气道正压通气（continuous positive airway pressure,CPAP）模式辅助通气;治疗组患者在对照组的基础上加用畲药食凉茶组方。两组患者均治疗3个月。比较两组患者的多导睡眠监测（polysomnography monitoring,PSG）指标、爱泼沃斯嗜睡量表（Epworth sleepiness scale,ESS）评分、体质量指数、临床疗效、血清MDA和AOPP水平。结果 治疗后,治疗组患者的睡眠呼吸暂停低通气指数（apnea hypopnea index,AHI）[（9.95±1.92）次/h]、氧减指数（oxygen desaturation index,ODI）[（17.04±2.61）%]、氧饱和度<90%时间（T90）[（10.03±1.95）%]、微觉醒指数（micro-arousal index,MAI）[（31.94±4.03）%]明显低于对照组,平均氧饱和度[（91.46±5.03）%]明显高于对照组,差异均有统计学意义（t分别为18.539、10.374、13.906、11.668、2.611,P<0.01）;治疗后,治疗组患者的ESS评分[（13.13±2.22）分]、体质量指数[（24.57±3.12）kg/m2]、血清MDA[（9.49±1.96）μmol/L]和AOPP[（70.70±8.30）μmol/L]水平明显低于对照组,差异均有统计学意义（t分别为3.313、2.670、4.723、3.506,P<0.01）;治疗组患者的总有效率（93.33%）高于对照组（66.67%）,差异有统计学意义（χ2=4.870,P=0.024）。结论 在西医常规治疗基础上,畲药食凉茶组方能进一步改善痰湿内阻型OSAHS患者的PSG指标和临床症状,提高治疗效果,且可降低氧化应激反应。
Objective To investigate the clinical efficacy of She medical diet cool tea compound in treating obstructive sleep apnea hypopnea syndrome (OSAHS) with syndrome of internal resistance of phlegm-dampness and its effect on serum levels of malondialdehyde (MDA) and advanced oxidation protein products (AOPP). Methods Sixty OSAHS patients with syndrome of internal resistance of phlegm-dampness treated in Lishui Hospital of Traditional Chinese Medicine from May 2019 to May of 2022 were selected and divided into two groups according to random number table method: control group and treatment group, with 30 cases in each group. The control group received continuous positive airway pressure (CPAP) assisted ventilation with non-invasive ventilator, and She medical diet cool tea compound was added to the treatment group on the basis of the control group. Both groups were treated for 3 months. Polysomnography monitoring (PSG), Epworth sleepiness scale (ESS) score, body mass index, the clinical efficacy, and serum levels of MDA and AOPP were compared between the two groups. Results After treatment, sleep apnea hypopnea index (AHI) [(9.95±1.92)times/h], oxygen desaturation index (ODI) [(17.04±2.61)%], oxygen saturation time <90% (T90) [(10.03±1.95)%], micro-arousal index (MAI) [(31.94±4.03)%] in the treatment group were significantly lower than those in the control group, while average oxygen saturation (SaO2) [(91.46±5.03)%] was significantly higher than those in the control group (t were 18.539, 10.374, 13.906, 11.668, 2.611, P<0.01). After treatment, ESS score (13.13±2.22), body mass index [(24.57±3.12) kg/m2], and serum levels of MDA [(9.49±1.96) μmol/L] and AOPP [(70.70±8.30) μmol/L] of the treatment group were lower than those of the control group (t were 3.313, 2.670, 4.723, 3.506, P<0.01). The total effective rate of the treatment group (93.33%) was higher than that of the control group (66.67%), and the difference was statistically significant (χ2=4.870, P=0.024). Conclusion Based on the conventional treatment of western medicine, She medical diet cool tea compound can further improve the PSG index and clinical symptoms of OSAHS patients with syndrome of internal resistance of phlegm-dampness, improve the therapeutic effect, and reduce oxidative stress response.
