知识与财富的链接
目的探索磁共振相位对比电影成像法(PC cine MRI)对广西巴马小型猪急性颅内高压致脑疝模型的脑脊液(cerebrospinal fluid, CSF)动力学监测。方法抽取10只猪股动脉血,向额颞顶叶内注血制成急性颅内高压致脑疝模型;监测平均动脉血压(mean arterial blood pressure, MAP)、颅内压(intracranial pressure, ICP)、脑灌注压(cerebral perfusion pressure, CPP)。用3.0T磁共振对所有实验动物注血前、注血后行常规颅脑磁共振T1WI轴位,T2WI轴位、冠、矢状位扫描以及以颈3(C3)椎体为中心,垂直于椎管的脑脊液流动序列(fast PC cine slice)扫描。比较注血前后ICP、MAP、CPP、CSF峰值流速绝对值和颈动脉峰值流速绝对值的变化情况。结果注射自体动脉血前ICP为(6.80±2.044)mmHg,MAP为(76.80±7.068)mmHg,CPP为(70.00±6.074)mmHg,CSF峰值流速绝对值为(243.20±77.671)mm/s,与注血后ICP为(52.20±1.619)mmHg,MAP为(142.80±12.399)mmHg,CPP为(90.50±12.250)mmHg,CSF峰值流速绝对值为(201.40±55.482)mm/s相比较,差异均有统计学意义(P < 0.01);注血前颈动脉峰值流速绝对值为(876.80±239.908)mm/s,与注血后颈动脉峰值流速绝对值为(799.40±241.829)mm/s相比较,差异无统计学意义(P > 0.05)。结论急性颅内高压致脑疝形成后,C3水平椎管内CSF流动呈现出低动力学改变,CSF流速波形图紊乱、畸形。PC cine MRI对CSF动力学的无创性测量可为急性颅内高压致脑疝动物模型的CSF动力学的改变提供重要依据,并为将来进一步研究损伤控制神经外科提供理论基础。
Zhou Jianguo;Zhu Xiaoling;Wei Wupeng;Huang Lixuan;Feng Yongbiao;Zhang Ling;Ma Xiangfei;Li Weixiong;Zhang Jianfeng;Ou Hesheng;Tang Huamin(Department of Emergency Medicine, the Second Affiliated Hospital of Guangxi Medical University, Nanning 530007, China;Graduate School of Guangxi Medical University, Nanning 530021, China;Department of Radiology, the Second Affiliated Hospital of Guangxi Medical University, Nanning 530007, China;Department of Radiology, the First People's Hospital of Nanning, Nanning 530022, China;Department of Radiology, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China;Department of Anesthesiology, the Second Affiliated Hospital of Guangxi Medical University, Nanning 530007, China;Research Section, Guangxi International Zhuang Hospital, Nanning 530201, China;Department of Emergency and First Aid Linkage Center, Guangxi International Zhuang Hospital, Nanning 530201, China)
