知识与财富的链接
通过腹腔注射四氧嘧啶构建糖尿病小鼠模型,研究极大螺旋藻对糖尿病小鼠的降血糖效果。结果表明：极大螺旋藻将糖尿病小鼠的空腹血糖从（28.24±1.92）mmol/L显著降低至（20.92±1.15）mmol/L;体质量显著提升至（26.12±1.31）g,接近正常组小鼠水平。此外,极大螺旋藻可有效降低糖尿病小鼠血清中的甘油三酯（triglyceride,TG）、总胆固醇（total cholesterol,TC）、低密度脂蛋白胆固醇（low density lipoprotein cholesterol,LDL-C）含量以及谷丙转氨酶（alanine aminotransferase,ALT）、谷草转氨酶（aspartate aminotransferase,AST）活性,分别下降47.67%、28.25%、18.47%、37.27%和28.86%,同时显著下调炎症因子白细胞介素-6(interleukin-6,IL-6)和肿瘤坏死因子-α(tumor necrosis factor-alpha,TNF-α)的表达,分别下降36.93%和41.08%;病理学分析显示,极大螺旋藻对糖尿病小鼠的胰腺与胸主动脉血管损伤有明显修复作用。综上,极大螺旋藻对糖尿病小鼠具有显著的降血糖作用,包括降低血糖、改善血脂代谢、减轻炎症反应以及改善肝脏、胰腺组织损伤。
This paper investigated the Hypoglycemic effect of Spirulina maxima on diabetic mice by building a diabetic mouse model by intraperitoneal injection of alloxan. The results showed that Spirulina maxima significantly reduced the fasting blood glucose of diabetic mice from （28.24±1.92） mmol/L to （20.92±1.15） mmol/L,and notably increased body weight to （26.12±1.31） g, close to the level of the normal group of mice. Additionally, Spirulina maxima effectively reduced the levels of triglyceride （TG）, total cholesterol （TC）, low density lipoprotein cholesterol （LDL-C）, alanine aminotransferase （ALT）, and aspartate aminotransferase （AST） activity in serum of diabetic mice by 47.67%, 28.25%, 18.47%, 37.27%, and 28.86% respectively. Meanwhile, the expression of inflammatory factors interleukin-6 （IL-6） and tumor necrosis factor-alpha （TNF-α）was down-regulated, with the decrease of 36.93% and 41.08% respectively. Pathological analysis showed that Spirulina maxima had a significant effect on repairing pancreatic and thoracic aorta vascular damage in diabetic mice. In summary, Spirulina maxima had significant Hypoglycemic effects on diabetic mice, including blood sugar reduction, lipid metabolism improvement, inflammatory response alleviation, and liver and pancreatic tissue damage enhancement.
