知识与财富的链接
目的：探讨肌肉能量技术（MET）联合核心稳定性训练（CST）治疗慢性非特异性下腰痛（NLBP）的疗效及其对血清白介素-1β（IL-1β）、白介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）的影响。方法：采用随机数字表法将200例NLBP患者随机分为对照组（常规护理）、试验组A（MET治疗）、试验组B（CST治疗）、试验组C （MET联合CST治疗）各50例,持续治疗4周后,比较4组患者魁北克腰痛障碍评分量表评分（QBPDS）、疼痛情况（VAS 评分）、改良日本骨科协会腰痛生活质量评分（JOA）、焦虑量表评分（HADS-A）、抑郁量表评分 （HADS-D）、睡眠质量评分（PSQI）、血清炎症因子（IL-1β、IL-6、TNF-α）。结果：治疗后,试验组A、试验组B、 试验组 C 的 QBPDS、VAS、HADS-A、PSQI 评分均较治疗前下降,JOA 评分较治疗前提高（P＜0.05）;其中 QBPDS、VAS、JOA试验组C较试验组A、试验组B改善更显著（P＜0.05）。治疗后,试验组A、试验组B、试验组C的血清IL-1β、IL-6、TNF-α水平均较治疗前降低（P＜0.05）,其中试验组C的IL-6水平较试验组A、试验组 B 改善更显著（P＜0.05）。NLBP 患者治疗前 IL-6 与 JOA 评分弱相关（r=-0.313,P=0.027）。结论：MET、CST、 MET 联合 CST 对 NLBP 均有效,可改善患者的症状,缓解疼痛、降低炎症因子水平,且联合治疗效果更佳; NLBP患者血清炎症因子IL-6水平与JOA评分负相关。
Objective: To investigate the efficacy of muscle energy technique (MET) combined with core stability training (CST) in the treatment of non-specific low back pain (NLBP), and to explore its impact on serum interleukin-1β (IL-1β), interleukin-6 (IL6), and tumor necrosis factor-alpha (TNF-α). Methods: A total of 200 NLBP patients were randomly divided into a control group (receiving routine care), test group A (receiving MET treatment), test group B (receiving CST treatment), and test group C (receiving combined MET and CST treatment), with 50 cases in each group. After 4 weeks of continuous treatment, the Quebec Back Pain Disability Scale (QBPDS) score, pain status (Visual Analog Scale [VAS] score), modified Japanese Orthopedic Association Back Pain Quality of Life Scale (JOA) score, anxiety scale score (Hospital Anxiety and Depression Scale-Anxiety [HADS-A]), depression scale score (Hospital Anxiety and Depression Scale-Depression [HADS-D]), sleep quality score (Pittsburgh Sleep Quality Index [PSQI]), and serum inflammatory factors (IL-1β, IL-6, TNF-α) levels were compared among the four groups. Results: After treatment, the QBPDS, VAS, HADS-A, and PSQI scores of test groups A, B, and C were significantly lower than those before treatment, while the JOA scores were significantly higher (all P＜0.05). Among them, the improvements in QBPDS, VAS, and JOA scores in test group C were more significant than those in test groups A and B (P＜0.05). After treatment, the serum levels of IL-1β, IL-6, and TNF-α in test groups A, B, and C were significantly lower than those before treatment (all P＜0.05), and the improvement in IL-6 level in test group C was more significant than that in test groups A and B (P＜0.05). There was a weak negative correlation between serum IL-6 level and JOA score in NLBP patients before treatment (r=-0.313, P=0.027). Conclusion: MET, CST, and their combination are all effective in treating NLBP, which can improve patients'' symptoms, relieve pain, and reduce serum inflammatory factor levels, with the combined treatment showing the best efficacy. Serum IL-6 level in NLBP patients is negatively correlated with JOA score.
