By discussing the connotation of "Spiritual Assistance" in Colleges and Universities Under Perspective of Socialist Core Values, the paper is meant to clarifies the compatibility between them and the necessity of Guiding the "Spiritual Assistance"with socialist core values, and preliminarily explores the significance of socialist core values to the top-level design of "Spiritual Assistance", and Guides the paths of "cultural poverty alleviation", "psychological adjustment" and "skill training" with socialist core valuesguides "cultural poverty alleviation" with socialist core values, which aims to The purpose is to further enhance the effectiveness of "spiritual poverty alleviation" in colleges and universities.