Objective To establish a method for the determination of 192 kinds of pesticides residues in Pu’er tea by gas chromatography tandem mass spectrometry (GC-MS/MS). Methods The sample of Pu’er sun tea was soaked in acetonitrile overnight, shaken and extracted, concentrated and purified by Clearnet TPT solid phase extraction column. The samples were determined by gas chromatography-tandem mass spectrometry with multi-reaction monitoring (MRM) mode and quantified by epoxy heptachlor. The method was validated according to the limit of detention (LOD), limit of quantitative (LOQ), and the percentage of recovery and linearity range. Results The correlation coefficients (r2) of all pesticides residues were more than 0.995 with the concentration range of 0.025-1.6 mg/L. The LODs and LOQs of the method were 0.0003-0.25 mg/kg and 0.0009-0.8 mg/kg, respectively. The average recoveries of pesticides ranged from 64% to 126%, and the relative standard deviations were less than 9.8% at spiked levels of 0.025, 0.05 and 0.1 mg/kg. Conclusion This method is sensitive, accurate and precise, which can meet the technical requirements for multi-pesticide residue detection.