Objective:To study the clinical curative effect of Huangqi decoction in the treatment of acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods:166 patietns with AECOPD were randomly divided into the regular group and observation group with 83 patients in each group.The regular group was treated with conventional western medicine,and the observation group was given Huangqi decoction on the basis of the regular group.The lelels of forced expiratory volume(FEV1),forced vital capacity(FVC),percentage of FVC FEV1(FEV1/FVC%),arterial oxygen pressure(PaO 2),arterial partial pressure of carbon dioxide(PaCO 2),tumor necrosis factor alpha(TNF-alpha),interleukin-1 beta(IL-1 beta),white blood cell interleukin-6(IL-6)in two groups before and treatment were observed.Results:The levels of FEV1,FEV1/FVC and PaO 2 in two groups after treatment were significantly higher than those before treatment(P<0.05),and those indciators of the observation were significantly higher than those of the regular group(P<0.05).The levels of PaCO 2,TNF-α,IL-1βand IL-6 in two groups after treatment were significantly lower than those before treatment(P<0.05),and the levels of PaCO 2,TNF-α,IL-1βand IL-6 in the observation were significantly lower than those of the regular group(P<0.05).Conclusion:The Huangqi decoction in treatment of patients with AECOPD can can reduce the level of inflammatory reaction,improve the arterial blood gas and lung function,improve the treatment effect,and is worthy of clinical application.