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A study on protonation equilibria in a series of amino-1-(substituted phenyl)pyrazoles

ISSN:0022-152X
1989年第26卷第6期
Article
A. Garrone,C. Tironi,R. Fruttero,A. Gasco


The ionization constants (proton gain) of 3-,4-, and 5-amino-1-(substituted phenyl)pyrazoles, have been measured in 10% v/v ethanol-water. pKa values show a good linear dependence on Hammett substituent constants. The reaction constants Q are in keeping with the respective protonation sites in the three series of monocations. The uv spectra of 1-(m-nitrophenyl)pyrazole and 1-(p-methoxyphenyl)pyrazole and of their 3-amino, 4-amino, 5-amino analogues recorded in acidic and neutral media, show that in the three series the first protonation site does not change with change in substituent at phenyl ring.

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ISSN:0022-152X
1989年第26卷第6期
Article

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