知识与财富的链接
目的探讨非酒精性脂肪肝(NAFLD)患者血清miR-122的表达水平,探索新的诊断NAFLD的生物学标记。方法选择临床确诊的NAFLD患者48例,健康对照组48例。留取血清,用实时荧光定量PCR方法检测血清miR-122的表达。统计学分析miR-122在两组间表达水平的差异。结果NAFLD患者血清miR-122的表达水平较对照组明显升高(P0.01)。结论miR-122可能参与了NAFLD的发病机制,有可能成为NAFLD新的诊断标记物。
Objective To investigate the expression of serum miR-122 in patients with nonalcoholic fatty liver disease(NAFLD),and to explore the new dagnostic biomarkers of NAFLD．Methods 48 patients with clinically diagnosed NAFLD and 48 healthy controls were selected．Their serum specimens were taken．The difference in expression levels of miR-122 between the two groups was statistically analyzed．Results The expression level of serum miR-122 in NAFLD patients was significantly higher than that in control group(P＜0．01)．Conclusion miR-122 may be involved in the pathogenesis of NAFLD and may become a new diagnostic marker for NAFLD．
