知识与财富的链接
帕金森病(PD)是一种隐匿性和进行性发展的神经退行性疾病,在65岁以上人口中约占2%～3%,是第二大常见的神经退行性疾病。PD的致病因素尚未明确,但α突触核蛋白(α-synuclein)的错误折叠和聚集所形成的路易小体被认为是PD的典型病理学改变。由于缺乏可靠的生物标志物,PD的早期诊断较难。本文总结了PD患者不同样本中检测出的α突触核蛋白的最新进展,包括体液(脑脊液、血液、唾液)和周围组织(皮肤、嗅觉黏膜、唾液腺、肠道黏膜),以期进一步了解PD的生物标志物研究。此外,还综述了针对α突触核蛋白治疗PD的新进展。
Parkinson disease (PD) is an insidious and progressive neurodegenerative disease. It is the second most common neurodegenerative disease affecting 1%-3% of the population over the age of 65. While the etiology of PD is complex, α-synuclein (α-syn) misfolding and aggregation is identified as the hallmark of PD. Due to lack of the reliable biomarkers, early diagnosis of this disease is difficult. In this review, we discuss recent research progresses in the development of PD biomarkers based on the detection of α-synuclein from different samples, including body fluids (cerebrospinal fluid, blood, saliva) and peripheral tissues (skin, olfactory mucosa, salivary gland, gut mucosa). Furthermore, we summarize the recent advances on the therapeutic approaches targeting α-synuclein in treating PD.
