Scientific research instruments are not only the basis of hospital scientific research platform, but also important educational and scientific research resources. Realizing the sharing and effective opening of scientific research instrument resources can better provide hardware support and basic guarantee for the hospital''s scientific and technological innovation, discipline construction, and personnel training.In this paper, by exploring the operation mechanism and management mode of the open sharing of scientific research instruments in hospitals, and integrating functions such as instrument management, reservation use, charging settlement and access monitoring by means of informatization, networking, and automation, a scientific research instrument sharing service platform is established,scientific management and effective utilization of scientific research instrumentsare realized, and professional service capabilities areimproved, and operating costs are balanced. Hence, the superior scientific research resources of the hospitalcan be effectively integrated, the degree of openness and sharing can be improved, and scientific and technological innovation as well as the society can be better served.