The conventional automatic generation control (AGC) strategy only takes the economic factors into consideration. However, for interconnected power grids, the hidden failure of communication outage may cause AGC control signal blocks followed by control units'' inability of power adjustment with the load fluctuation. In this paper, a novel AGC strategy was proposed to improve the conventional one by taking both strategy of economic dispatch (ED) and load frequency control (LFC) into consideration. The novel AGC strategy has considered the communication outage probability and was prophylactic, so that it could let the impact of communication outage down. The ED control of the novel AGC strategy was designed against the long-term substantial load fluctuation by adjusting the power of those AGC units with high communication outage probability according to the load forecasting as much as possible. While the LFC strategy of the novel AGC strategy was designed against short-term and unpredictable slight load fluctuation by adjusting the power of those AGC units with low communication outage risk. The IEEE-118 system is employed to verify the effectiveness of the novel AGC strategy. The simulation results indicate that the novel control strategy has the ability of improving the dynamic stability of power system, excellent economy and engineering application value.