知识与财富的链接
炎性小体是先天免疫系统的重要组成部分,其中研究热点为NOD样受体蛋白3(NOD-like receptor protein 3,NLRP3)炎性小体,通过激活相应的信号途径参与多种慢性炎症疾病的发生发展。近年来,NLRP3炎性小体在动脉粥样硬化、非酒精性脂肪性肝病、阿尔茨海默病、慢性阻塞性肺疾病和慢性肾脏病等疾病的发生进程中,发挥着重要作用。该文就炎性小体与慢性炎症相关疾病的研究进展作一综述。
［Abstract］ Inflammasomes are important components of the innate immune system, among which NOD-like receptor protein 3(NLRP3) is a research hotspot. NLRP3 is involved in the occurrence and development of various chronic inflammatory diseases by activating the corresponding signaling pathways. Recent researches demonstrate that inflammasome NLRP3 plays a vital role in the pathogenesis of various diseases, such as atherosclerosis(AS), non-alcoholic fatty liver disease(NAFLD), Alzheimer ′s disease(AD), chronic obstructive pulmonary disease(COPD) and chronic renal disease. In this paper, we review the research progress of inflammasomes and chronic inflammatory related diseases.
