Objective To investigate the effects of sugammadex on neuromuscular blockade recovery in patients with general anesthesia undergoing thoracoscopic-laparoscopic radical esophagectomy.Methods Ninety-six patients with general anesthesia undergoing thoracoscopic-laparoscopic radical esophagectomy were selected,61 males and 35 females,aged 18-65 years,ASA physical statusⅠorⅡ.Patients were divided into two groups:control group(group C)and sugammadex group(group S),48 patients in each group using a random digital table.The two groups received the same anesthesia induction and intraoperative general anesthesia maintenance program,and neuromuscular blockade was assessed with a train-of-four(TOF)stimulus.When T2 of TOF appeared at the end of the surgery,group C received intravenous neostigmine 0.05 mg/kg combined with atropine 0.02 mg/kg,and group S received intravenous sugammadex 2 mg/kg.The time from the administration of neuromuscular blockade antagonists to the recovery of TOF ratio(TOFr)to 0.9,and the time from the administration of neuromuscular blockade antagonists to the extubation(time of extubation)were recorded.The incidence of residual neuromuscular blockade was calculated 5,15,and 30 minutes after administration of neuromuscular blockade antagonists.The time of first postoperative flatus and feces was recorded.The incidence of postoperative nausea and vomiting(PONV)was calculated.Results Compared with group C,the time to restore TOFr to 0.9 was significantly shorter[(2.2±0.9)minutes vs(16.2±3.4)minutes,P<0.01]and the time to extubation was significantly shorter[(12.3±2.0)minutes vs(33.0±5.1)minutes,P<0.01]after the administration of neuromuscular blockade antagonists,and the incidence of residual neuromuscular blockade was significantly lower 5 and 15 minutes after the administration of neuromuscular blockade antagonists(12%vs 100%and 0%vs 65%,P<0.01),the incidence of PONV was significant lower[7 cases(15%)vs 19 cases(40%),P<0.05],and the time to postoperative first flatus was significantly shorter[(23.4±2.1)hours vs(30.5±3.1)hours,P<0.01]in group S.There were no significant differences in the time to postoperative first feces between the two groups.Conclusion Sugammadex can reverse the residual neuromuscular blockade induced by rocuronium within shorter time and decrease the incidence of residual muscular blockade in patients with thoracoscopic-laparoscopic radical esophagectomy,promote the recovery of postoperative gastrointestinal motility,reduce the incidence of postoperative complications and improve the quality of postoperative neuromuscular blockade recovery.