［Abstract］　Objective　To summarize the clinical experience of extracorporeal cardiopulmonary resuscitation(ECPR) as circulatory assist in adult patients with cardiac arrest. Methods　A total of 26 cardiac arrest patients who were admitted to the Emergency Intensive Care Unit(EICU) of the People′s Hospital of Guigang for ECPR treatment from April 2019 to December 2020 were collected. A retrospective analysis was performed on the patients′ medical records, and the clinical data, laboratory examination results, and various parameters and indicators were compared between the survival group and the death group. Results　Among the 26 patients, 9 cases were successfully weaned from extracorporeal membrane oxygenation(ECMO) and 6 cases survived to hospital discharge. All the survivors were the patients with in-hospital cardiac arrest(IHCA).Twenty cases died. The initial lactate value and the lactate values 6 and 12 hours after ECPR in the survival group were lower than those in the death group. The values of mean arterial pressure 6 and 12 hours after ECPR in the survival group were higher than those in the death group. The velocity time integral of the left ventricular outflow tract 6 and 12 hours after ECPR in the survival group was higher than that in the death group. There were significantly differences in the above indicators between the two groups(P<0.05). Conclusion　ECMO can save the lives of some patients who have failed conventional cardiopulmonary resuscitation(CCPR) by providing emergency cardiopulmonary bypass assistance.