This paper reports treating blood-stasis Syndrome of coronary heart disease(CHD)angina pectoris with Huoxue granule(HXG)and its effect on hemorrheology.50 cases were divided into two groups,one group was treated with HXG,another with placebo(single blind).In HXG group the total effective rate for angina pectoris was 86.7%,marked effective rate 33.3%,effective rate for ischemic ECG changes was 40%.All of these were better than placebo group statistically(P<0.025,0.005, 0.025).Experimental results showed that HXG was able to inhibit platelet adherence and aggrega- tion,decrease whole blood viscosity in low shear, prolong reacting time and coagulating time of thrombolastrogram,improve erythroid deformability.So the mechanism for HXG in treating angina pectoris may be preventing coronary artery injury caused by platelet adherence,aggregation,release and hypercoagulation,improving microcirculation and myocardial blood supply These results suggest that HXG is an effective antianginal medicine.