Fetal cleft lip and palate is the most common congential facial anomaly, and they are remarkably correlated with fetal outcome and the presence of additional fetal structural and chromosomal abnormalities. But it is difficult to be diagnosed prenatally. Ultrasonography is the most common method to detect it. Cleft lip and anterior cleft palate could be identified by using coronal and axial plane of two-dimensional and three-dimensional ultrasound reconstruction after fetal specimens experiment and embryonic lip and palate development study. It is mainly to detect indirect clue for diagnosis of secondary cleft palate which is difficult to display directly,so it now can not be diagnosed prenatally.