Objective: To study the efficacy of periarticular multimodal analgesic drugs injection in total hip arthroplasty. Methods: Seventy-six patients undergoing total hip arthroplasty were randomly divided into two groups,38 patients received periarticular intraoperative injection of multimodal analgesic drugs,and others not do. Pain of patients were evaluated with a visual analog scale postoperatively,and all patients received patient-controlled analgesia for 24 hours after surgery. The consumption of patient-controlled analgesia was recorded at different time-points. Results: Compared to the control group,visual analog scores for pain of the patients of injected group had significantly lower in the post-anesthetic-care unit and four hours after surgery. Patients of the injected group used significantly less patient-controlled analgesia at 6,12 hours,and over the first 24 hours after surgery than the control group. No adverse effects resulted from the multimodal analgesic drugs were noted in the injected group. Conclusion: Periarticular injection of multimodal analgesic drugs in total hip arthroplasty can significantly reduce the postoperative pain of patients and the consumption of patient-controlled analgesia.