知识与财富的链接
目的：观察平喘合剂对哮喘豚鼠血浆嗜酸细胞阳离子蛋白(ECP)、支气管肺泡灌洗液(BALF)中白细胞介素-5(IL-5)水平及炎症细胞计数变化的影响。方法：采用常规计数法测BALF中嗜酸粒细胞、中性粒细胞、淋巴细胞计数,运用ELISA法测IL-5,放免法测ECP。结果：治疗后平喘合剂、地塞米松组嗜酸粒细胞、中性粒细胞、淋巴细胞数量,ECP、IL-5水平比治疗前明显降低(P<0．05或P<0．01),平喘合剂、氨茶碱、地塞米松、定喘止咳片各组间比较,差异均无显著性。结论：平喘合剂可降低炎症细胞计数、ECP、IL-5而治疗哮喘。
Objective:To observe the effect of Pingchuan Mixture (PCM) on plasma eosinophil cation protein (ECP), interleukin-5 in bronchial alveolar lavage fluid (BALF) and inflammatory cell count in experimental guinea pigs with asthma. Methods:The eosinophil, neutrophil, lymphocyte count were conducted by conventional method, IL-5 was detected by ELISA and ECP determined by RIA. Results:Levels of eosinophil, neutrophil, lymphocyte, ECP and IL-5 after treatment were significantly lower than those before treatment, the difference between groups treated respectively by PCM, aminophylline, dexamethasone and Dingchuan Zhike Tablet was insignificant. Conclusion:PCM could treat asthma by reducing the inflammatory cell count, ECP and IL-5.
