知识与财富的链接
目的 改进抗高血压药物阿折地平的合成工艺。方法 以二苯甲胺和环氧氯丙烷为起始原料,经取代,酯化, 酸化,缩合等反应制得抗高血压药物阿折地平。结果与结论 目标化合物的结构经1H-NMR、质谱确证。总收率为30.88%,比文献收率提高了10.62%。改进后的方法操作简便,有利于工业化生产。
Aim To improve the synthetic procedure of azelnidipine.Methods Azelnidipine was synthesized from aminodiphenylmethane and epichlorohydrin via substitution,esterification,acidification,condensation,etc.Results and conclusion The structure of target compound was confirmed by ^1H-NMR,MS.The overall yield of the process is 30.88%.Compared with the reported method,the overall yield is 10.62% higher.This synthetic process is suitable for industrial preparation by its convenient operation.
