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Cyclocondensation of 2-iodobenzaldehyde with benzamidines catalyzed by copper(I) iodide: a route to 2-arylquinazolines

ISSN:0009-3122
2011年第46卷第12期
A.?V.?Vypolzov1,D.?V.?Dar’in1,S.?G.?Ryazanov1,P.?S.?Lobanov1

The reaction of benzamidines with 2-bromo- and 2-iodobenzaldehydes catalyzed by the CuI/L-proline system has been studied. Reaction with 2-iodobenzaldehyde leads to the formation of quinazolines in good yield. 2-Bromobenzaldehyde forms 2-arylquinazolines in low yield due to the competing reaction involving two molecules of amidine leading to a dihydrotriazine.

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ISSN:0009-3122
2011年第46卷第12期

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