知识与财富的链接
目的 探讨CKS1和p27在乳腺癌中的表达情况及其临床意义。方法 应用免疫组织化学SP法检测149例乳腺癌患者组织标本中CKS1和p27的表达水平,结合临床病理资料进行统计学分析。结果 乳腺癌组织中CKS1的表达与淋巴结转移和临床分期有统计学意义（P<0.05）。p27的表达与淋巴结转移显著负相关（P<0.05）,与临床分期和肿瘤分化程度无相关性。多因素分析发现临床分期（P<0.01）、淋巴结转移（P<0.01）、CKS1（P<0.01）和p27（P<0.01）的表达对预后的影响有统计学意义。CKS1与p27表达呈显著负相关（P<0.05）。结论 CKS1和p27可能在乳腺癌的发生发展中发挥重要的作用,二者将来可能作为乳腺癌治疗的靶点之一。
Objective To investigate the expression of CKS1 and p27 protein in breast cancer and analyze their correlation with clinical parameters. Methods Immunohistochemical staining method of SP was used to examine 149 samples of breast cancer. Results The expression of CKS1 in breast cancer was significantly associated with lymph node metastasis and clinical stage (P<0.05). No correlation was found between expression of CKS1 and tumor differentiation. Significantly inverse correlation was found between expression ...
