知识与财富的链接
目的 探讨系统性红斑狼疮(SLE)患者外周血中D-二聚体水平的变化及其在SLE继发抗磷脂综合征(APS)中的意义. 方法 采用免疫比浊法测定104例SLE患者和50例正常人外周血中D-二聚体水平,并比较D-二聚体水平在SLE继发及无继发APS组间的差别. 结果 SLE组外周血中D-二聚体水平明显高于正常人组,差别有显著统计学意义(t=5.172,P<0.0001).与D-二聚体水平正常组SLE患者相比,D-二聚体水平升高组SLE患者的SLEDAI积分、IgG水平、GLO水平、胸膜炎和心包炎发生率明显升高(P<0.05～0.0001),Hb、C3、ALB水平明显降低(P<0.05～0.0001).SLE继发APS患者外周血中D-二聚体水平明显高于无继发APS的患者(t=2.757,P=0.013);在伴肺动脉高压的SLE患者中继发APS患者外周血中D-二聚体水平仍高于无继发APS的患者(t=3.213,P=0.031),而在不伴肺动脉高压的SLE患者中继发APS和无继发APS组间D-二聚体水平无明显差别(P>0.05). 结论 SLE患者外周血中D-二聚体水平明显升高,其升高与疾病活动性和继发APS相关.
AbstractObjectiveTo investigate the significance of plasma D-dimer in systemic lupus erythematosus (SLE) with secondary antiphospholipid syndrome(APS). MethodsThe levels of plasma D-dimer in 104 SLE patients and 50 normal individuals were measured by immunoturbidimetry. ResultsThe level of D-dimer in SLE was obvious higher than that in normal individuals(t=5.172,P<0.0001). The SLE disease activity score, levels of immunoglubulin G and glubulin, incidence of pleurisy and pericarditis in SLE subgroup1 with rised level of D-dimer were higher than those in SLE subgroup2 with normal level of D-dimer (P<0.05~0.0001). The levels of hemoglobin, complement 3 and albumin in subgroup1 were lower than those in subgroup2 (P<0.05~0.0001). The level of plasma D-dimer in SLE with secondary APS was obvious higher than that in SLE without secondary APS(t=2.757,P=0.013). In patients of SLE with pulmonary arteria hypertension, the level of plasma D-dimer in patients with secondary APS was obvious higher than that without secondary APS(t=3.213,P=0.031). In patients of SLE without pulmonary arteria hypertension, the level of D-dimer showed no difference between SLE with and without secondary APS(P>0.05). ConclusionThe level of plasma D-dimer in patients with SLE rised obviously. Its rise was associated with disease activity and secondary APS in SLE.
