知识与财富的链接
炎症复合体(inflammasome)是胞浆内一组复杂的多蛋白复合体,是胱天蛋白酶(caspase)-1活化所必需的反应平台,调控白介素(interleukin,IL)-1β、IL-18、IL-33等促炎细胞因子的加工及活化,参与天然免疫系统的激活.核苷酸结合寡聚化结构域样受体(nucleotide-binding and oligomerization domain-like receptors,NLRs)是胞浆内重要的模式识别受体,能感知胞内病原微生物产物及代谢性应激,起始炎症复合体的组装,是构成炎症复合体的核心成分.综述了炎症复合体和NLRs研究现状及其在炎症反应中的作用.
Inflammasome is a multiprotein complex and oligomeric platform that dimerizes and thereby activates cysteinyl aspartate-specific protease (caspase)-1. Caspase-1, also known as the interleukin (IL)-1β-converting enzyme (ICE), is the prototypical member of the inflammatory caspases and involved in regulating maturation of IL-1β, IL-18, and IL-33, key cytokines for the recruitment and engagement of inflammatory cells. Nucleotide-binding and oligomerization domain-like receptors (NLRs), which detect intracellular pathogens or other ‘alarms’, promote the assembly of inflammasome. Some evolutionary aspects and biochemical studies were reviewed, underlining the role of inflammasomes in infection as well as inflammatory diseases.