知识与财富的链接
目的探讨扩张型心肌病（DCM）患者超敏C反应蛋白（hs—CRP）水平与心功能的关系以及临床意义。方法比较hs—CRP正常组与hs—CRP升高组间NYHA心功能分级、左心室射血分数（LVEF）、左心室舒张末内径（LVEDD）的差异。分析不同NYHA分级患者的hs—CRP水平,并对hs—CRP与LVEF、LVEDD进行相关性分析。结果hs—CRP正常组NYHA分级为2．06±0．90级,LVEF为（38．58±5．98）％,LVEDD为58．94±6．14mm,hs—CRP升高组NYHA分级为2．89±0．88级,LVEF为（33．46±6．55）％,LVEDD为66．87±9．34mm,两组相比差异有显著性（P〈0．05）。NYHAI级组hs—CRP为2．66±1．80mg／L,Ⅱ级组为5．02±3．27mg／L,II级组为5．25±3．18mg／L,IV级组为8．84±2．60mg／L,Ⅱ级组、Ⅲ级组hs—CRP水平明显高于I级组（P〈0．05）,Ⅳ级组明显高于前3组（P〈0．001）。hs—CRP水平与LVEF呈负相关（r=-0．438,P〈0．00t）,与LVEDD正相关（r=0．346,P〈0．01）。结论hs—CRP水平与DCM患者心功能改变相关,hs—CRP可作为DCM患者心功能恶化的预测指标。
ObjectiveTo investigate the relationship between high sensitive C-reactive protein(hs-CRP) and cardiac function in patients with dilated cardiomyopathy(DCM). MethodsWe compared the differences of NYHA classes,left ventricular ejection fraction(LVEF) and left ventricular end diastolic diameter (LVEDD) between normal hs-CRP group and elevated hs-CRP group,and analyzed hs-CRP levels of different NYHA classes,then investigated the correlation between hs-CRP and LVEF and between hs-CRP and LVEDD. ResultsThe NYHA stage,LVEF,LVEDD were 2.06±0.90,(38.58±5.98)% and 58.94±6.14mm respectively in normal hs-CRP group,while those were 2.89±0.88,（33.46±6.55）% and 66.87±9.34mm in elevated hs-CRP group,and there were significant differences between the two groups.The hs-CRP was 2.66±1.80mg/L in NYHAⅠgroup,while that was 5.02±327mg/L in Ⅱgroup, 5.25±3.18mg/L in Ⅲ group,and 8.84±2.60mg/L in Ⅳ group.Levels of hs-CRP in Ⅱgroup and Ⅲ group were both significantly higher than those inⅠgroup(P<0.05),and the levels in Ⅳ group were strikingly higher than other three groups(P<0.001). Levels of hs-CRP had negative correlation to LVEF(r=-0.438,P<0.001),and positive correlation to LVEDD(r=0.346, P<001).ConclusionIt is reasonable to believe that hs-CRP is associated with cardiac function in patients with DCM,and hs-CRP may be an useful index to predict the prognosis.
