The present study examined the direction of the relation between sex role self-concept and depression. A total of 23 males and 32 females were given the Personal Attributes Questionnaire and the Beck Depression Inventory at two times separated by a 3-month interval. Results of a cross-lagged panel correlational analysis found no evidence for sex role orientation as a cause of depression. Instead, the data suggested that emotional well being precedes self-perceived instrumentality, but the influence of third variables could not be overlooked. The implications of these data are discussed with particular reference to the need for more complex theoretical formulations of the relation between self-perceived instrumentality and adjustment.