Aim To observe the bood supply regularity of advanced hepatocellular carcinoma for living human body.Methods Intraoperative hepatic artery and portal vein catheterieations were performed on sixteen patients with advanced hepatocellular carcinoma undergoing laparotomy,cathrters were inserted into hepatic artery and portal vein proper and the cathers were connected to IDDS which was implanted under the skin of abdominal wall.76% meglucarmine diarieoate was injected through the IDDS to observe tumors blood supply and to take desired spot films.Results Satisfactory radiological manifestion of hepatic artery and portal vein was obtained;the tumor blood supply was only came from heptic artery in nine cases and was only came from portal vein in one case,and was came from both hepatic artery and portal vein in six cases.Conclusion The difference of tumor blood supply between living human body and dead body or animal experiment was exist.The interventional therapy of advanced hepatocellular carcinoma should be used individual principle according to practical state of blood supply for every patient. [