One of the remarkable characteristics of the current development of China's national economy is the increase of uncertainties, which makes the traditional method more and more unsuitable for the current economic development in the real estate investment process. Based on the option game theory, the investment decision making of real estate is analyzed here, the investment optimization mathematic model established, and Nash Equilibrium discussed. Through case studies, we analyze the application of game option in the real estate, which is put under symmetrical duopoly. The conclusions will contribute to both the theory on and practice of the present investment in the real estate enterprise.