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Bioorganic & medicinal chemistry letters
ISSN：0960-894X
1999年第9卷第15期
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T Fryatt,D T Goroski,Z D Nilson,C J Moody,H D Beall
1. School of Chemistry, University of Exeter, Stocker Road, Exeter EX4 4QD, Devon, U.K.;2. Department of Pharmaceutical Sciences, The University of Montana, Missoula, MT 59812, U.S.A.;1. Instituto de Ciencias Exactas y Naturales, Universidad Arturo Prat, Casilla 121, Iquique, Chile;2. Facultad de Ciencias de la Salud, Universidad Arturo Prat, Casilla 121, Iquique, Chile;3. Bioanalysis and Pharmacology of Bioactive Lipids Laboratory, Louvain Drug Research Institute, Université Catholique de Louvain, 72 Avenue E. Mounier, BPBL 7201, 1200 Brussels, Belgium;4. Toxicology and Cancer Biology Research Group, Louvain Drug Research Institute, Université Catholique de Louvain, 73 Avenue E. Mounier, GTOX 7309, 1200 Brussels, Belgium;5. Departamento de Química, Facultad de Ciencias Básicas Universidad de Antofagasta, Casilla 170, Universidad de Antofagasta, Chile;1. School of Physical Science and Technology, Southwest University, Chongqing 400715, China;2. Department of Applied Physics, School of Physical Electronics, University of Electronic Science and Technology of China, Chengdu 610054, China;3. College of Electronic and Information Engineering, Southwest University, Chongqing 400715, China;1. Key Laboratory of Luminescence and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, College of Pharmaceutical Sciences, Southwest University, Chongqing, 400715, People’s Republic of China;2. Institute for Drug and Instrument Control of Health Dept GLD of PLA, Beijing, 100071, People’s Republic of China;1. Key Laboratory of Small Functional Organic Molecule, Ministry of Education and Jiangxi's Key Laboratory of Green Chemistry, Jiangxi Normal University, Nanchang, Jiangxi 330022, China;2. Beijing National Laboratory for Molecular Science (BNLMS), CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China;1. School of Electrical and Information Engineering, Tianjin University, Tianjin, 300072, China;2. School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, China;3. School of Chemical Engineering and Technology, Hebei University of Technology, Tianjin, 300130, China


The effects of functional group changes on the metabolism of novel quinolinequinones by recombinant human NAD(P)H:quinone oxidoreductase (NQO1) are described. Overall, the quinolinequinones were much better substrates for NQO1 than analogous indolequinones, with compounds containing heterocyclic substituents at C-2 being among the best substrates.

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Bioorganic & medicinal chemistry letters
ISSN：0960-894X
1999年第9卷第15期
关 注

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