知识与财富的链接
目的：研究和阐明组胺H1受体阻断剂对大鼠空间记忆的作用机制。方法：采用八臂迷宫学习的程序研究大鼠的空间记忆。结果：在学习过程中，腹腔内注射第一代组胺H1受体阻断剂苯海拉明（5mg/kg)或美吡拉明（20mg/kg)显著性地引起空间记忆障碍，苯海拉明（5，10mg/kg)、美吡拉敏（50mg/kg)则浓度依赖性且显著性地引起空间记忆再生过程的障碍。相反，新型组胺H1受体阻断剂依匹斯汀（50mg/kg)对大鼠的学习和记忆再生过程均无明显作用。他克林（1mg/kg)可改善苯海拉明（10mg/kg)、美吡拉敏（50mg/kg)所致的记忆障碍。结论：中枢组胺H1受体参与了调节大鼠空间记忆的作用，而且其作用主要与组胺神经及胆碱能神经相关。
ATM: To evaluate effects of certain H1-antagonists on spatial memory with 8-arm radial maze performance of rats. METHODS: Eight-arm radial maze performance was used to measure spatial memory in rats. RESULTS: Chronic treatments of classical H1-antagonists, diphenhydramine (5 mg/kg) and pyrilamine (20 mg/kg) impaired acquisition memory process regarding both parameters of radial maze performance, In addition, the memory retrieval process was also impaired significantly by a single administration of diphenhydramine (5, 10 mg/kg) and pyrilamine (50 mg/kg). However, the newly developed H1antagonist, epinastine caused no appreciable effect on both acquisition and retrieval memory even at a high dose of 50 mg/kg. The memory deficit induced by diphenhydramine (10 mg/kg) or pyrilamine (50 mg/kg) was reversed by tacrine (1 mg/kg). CONCLUSION: Histamine H1-receptors plays a certain role in spatial cognition, and its action may be due to both histaminergic and cholinergic neurons.