知识与财富的链接
目的探讨食管支架置入术后影响中晚期食管癌患者生存期的因素。方法回顾性分析103例接受金属覆膜食管支架置入术的中晚期食管癌患者的临床资料,选择性别、年龄、食管瘘、肿瘤长度、浸润深度、分化程度、临床分期、组织类型、术后化疗和术后放疗10个可能对食管支架置入术预后产生影响的因素,应用Cox回归模型分析其对预后的影响。结果单因素Cox回归分析显示食管瘘、肿瘤长度、浸润深度、分化程度及临床分期均对预后有显著影响（P均〈0.05）。进一步行Cox模型多因素分析,显示肿瘤分化程度及临床分期为影响预后的独立因素（P均〈0.05）。结论影响食管支架置入术后中晚期食管癌患者生存期的主要因素是肿瘤分化程度及临床分期;支架置入术后进一步放疗和化疗不能延长生存期。
Objective To assess the impact factors on survival time of patients with advanced esophageal cancer after stent implantation. Methods Data of 103 patients with advanced esophageal cancer who received covered endoscophageal stent implantation were retrospectively analyzed. Cox regression analysis was performed to examine the following factors on survival time, such as age, gender, fistula, tumor length, tumor invasion depth, pathologic type, grade of cell differentiation, clinical tumor stage, postoperative chemotherapy and radiotherapy. Results Single factor Cox regression analysis showed that fistula, tumor length, tumor invasion depth, grade of cell differentiation and clinical tumor stage had significant influence on prognosis (all P<0.05). Multiple Cox regression analysis showed that only grade of cell differentiation and clinical tumor stage were independent influence factors on prognosis (both P<0.05). Conclusion Grade of cell differentiation and clinical tumor stage are the major impact factors of prognosis that affect the survival of patients with unresectable esophageal carcinoma after stenting. There is no benefit for survivals treated with radiotherapy and/or chemotherapy after esophageal stenting.