【Objective】 This study observed the brains and immune organs contrapose of a transgenic cloned cattle of neonatal death.【Method】 Common pathological anatomy and histological common paraffin section-hematoxylin-eosin staining technique were applied.【Result】 The body of the transgenic cloned cattle was bigger than common cattle with harder osseous texture and no obvious appearance changes in immune organs.The layer structure of cerebral cortex was very clear,only had some mild congestion and hemorrhage in a patch.The cortex of cerebellum was divided into three layers,the arachnoid had a slight congestion.There was a mild congestion in red pulp of spleen with scattered hemosiderosis;clear periarterial lymphatic sheath and a great deal of splenic nodule could be seen in white pulp,but both containing few lymphocytes.There was a capillary dilatation and congestion of lymph nodes,especially in medulla;more and intensive lymphocytes in cortex,but the typical lymphoid nodules which contained germinal center were sparse,the medullary cord was not obvious,the capsule and trabecula were not developed.The thymus blood vessels on capsule and trabecula had a congestion;abundant lymphocytes and scattered thymocytes in cortex;lymphocytes also were intensive in medulla and large number of macrophages among lymphocytes,eosinophilic thymic corpuscles were visible,but not fully developed.【Conclusion】 This cloned cattle had a developed brain with no significant pathological changes,while disproportion existed in immune organs’ development.