知识与财富的链接
目的 制备姜黄素自微乳化释药系统（Cur-SMEDDS）,并考察其体外释药性能。方法 测定姜黄素在各辅料中的溶解度,绘制伪三元相图筛选自微乳化基质,以粒径和溶解度为指标确定最佳处方,并对Cur-SMEDDS的体外释药性质进行研究。结果 Cur-SMEDDS最佳处方组成为：EO-Cremophor RH40-Transcutol P比例为30∶52.5∶17.5,乳化后微乳的平均粒径为36.14 nm。结论 成功制备了Cur-SMEDDS,可显著改善姜黄素的溶解度,有望提高姜黄素的口服生物利用度。
OBJECTIVE To prepare the curcumin self-microemulsifying drug delivery system(Cur-SMEDDS) and study its release characteristics in vitro.METHODS The optimalum formulations of Cur-SMEDDS were screened by solubility experiment,and pseudo-ternary phase diagrams,with average particle size and solubility as parameters.The release curves of Cur-SMEDDS in different release mediuma were measured.RESULTS The optimumal formulation of Cur-SMEDDS was composed of Ethyl oleate/Cremophor RH40/Transcutol P with weight ratio...
