To summarize the research process of universal herbal pair containing aconitine in recent years, including clinical application, chemical research, pharmacological and toxicological research, apply theoretical bases of the aconite root species safely and effectively used in clinical application. Literatures on universal herbal pair containing aconitine in recent years were summarized and analyzed. Suitable compatibility of Aconitine root species can decrease toxicity and increase efficacy, enlarge applied range. There are some advancements in studies on reducing the toxicity and increasing efficacy of aconitine by using compatibility at present, but many researches are superficial, so it is necessary for us to further study the mechanism of detoxification and synergism by using compatibility, in order to apply theoretical bases of clinical application.