The gold orefield in Xiaoqinling-Xiong’ershan area of western Henan Province is one of the most important production areas of quartz vein gold deposits in China. To investigate the probable material sources of the gold deposits, the authors carried out isotope and REE Au abundance studies for the relationships of old strata of Taihua Group, granite of Yanshanian period, and Mesozoic intermediate-basic dykes to the main gold deposits in the orefield. The results show that the Taihua Group, the granite and the intermediate-basic dykes were unlikely to be material sources of the gold deposits. The metallogenic materials of the orefield were mainly derived from various geological bodies that participated in the interaction process between the crust and the mantle in the environment of the Qinling orogenic belt. The ore-forming fluids mainly originated from the mantle. The intermediate-basic dykes afforded neither gold materials nor fluids to gold deposits, and they came into being in a background of intense interaction between the mantle and the crust.