In the research of pharmacokinetics of traditional Chinese medicine it is helpful, if pharmacodynamic indexes are timely introduced into observation, to improving the characterization of the dynamic process in vivo of the tested drugs even though the characterization represents limited components that can be tested from the drugs. Nevertheless, such problems as how to conduct the experiment of pharmacodynamics, how to choose testing indexes and what is the characteristics of pharmacodynamics of traditional Chinese medicine should be taken into consideration in the research. Based on the researches already done and in comparison with literatures abroad this article discusses these problems as mentioned above and holds that in the experiment of pharmacodynamics end indexes should be taken as the main choice so as to be able to reflect and grasp the dynamic process of curative effects in vivo as a whole.