知识与财富的链接
目的:探讨槐果碱及氧化槐果碱对昆明小鼠的急性毒性反应.方法:通过向昆明小鼠尾静脉注射不同浓度的槐果碱及氧化槐果碱溶液,观察并记录槐果碱及氧化槐果碱对小鼠的毒性反应.利用SPSS13.0统计学软件计算其对小鼠的半数致死量( LD50).结果:昆明小鼠对槐果碱及氧化槐果碱单次尾静脉注射LD50分别为63.94,250.37 mg·kg -1,二者95％可信区间分别为56.49～73.08 mg· kg-1,219.05～288.02 mg·kg-1.结论:槐果碱和氧化槐果碱单次尾静脉注射对昆明小鼠有一定的毒性,槐果碱的氧化产物毒性明显降低.
Objective: To explore the acute toxicity of sophocarpine and oxysophoca rpine in Kunming mice. Method: The drugs were administered in mice via the tail vein injection. The toxic reactions were recorded and the medium lethal dose (LD50) was calculated by spss 13.0. Result: The LD50 of sophocarpine and oxysophocarpine was 63.94, 250.37 mg·kg-1, its 95% confidence interval was 56.49-73.08 mg·kg-1 and 219.05-288.02 mg·kg-1, respectively. Conclusion: Acute toxicity experiment showed that the sophocarpine and oxysophocarpine have some toxic effects on mice, and the former is more poisonous than the latter.
