知识与财富的链接
目的本研究旨在探讨高频率低能量的振动力学刺激对骨质疏松性骨折愈合的影响。方法59只大鼠建立大鼠卵巢切除骨质疏松模型,建模成功后构建股骨骨折模型,并随机分为振动力学刺激组和对照组。骨折后第5天开始对振动组使用高频率低能量振动平台(35Hz,峰振幅0.3重力加速度)行每天20min的振动力学刺激,对照组则行假治疗。每周摄X线片观察骨折愈合的情况,并采用显微计算机断层扫描和生物力学测试评估骨痂生成的情况及其力学属性。结果 X线随访显示,振动组的骨折愈合速度和愈合率均优于对照组。前者新生矿化骨痂的体积在治疗后第2周和第4周时均显著高于后者。第8周时,振动组成熟骨痂的体积以及整体的力学强度均显著优于对照组。结论高频率低能量振动力学刺激可促进骨质疏松性骨折的愈合。
Objective To explore the effects of low-magnitude high-frequency vibration stimulation(LHMFV) on osteoporotic fracture healing.Methods Closed femoral shaft fracture was established in 59 SD rats following bilateral ovariectomy.The rats were randomly divided into the vibration group and the control group.The LMHFV treatment(35Hz with peak vibration 0.3 Gravity acceleration) was performed to the rats at vibration group for 20 minutes every day beginning at the 5-day after the fracture.Sham-treatment was performed to the rats at the control group.Weekly radiographies were taken to assess the healing status.Three-dimensional quantification of mineralized callus formation was performed with micro-CT.Mechanical outcomes were checked with four-point-bending tests.Results Radiographic follow-up results showed that the healing rate of rats in the vibration group was higher than that in the control group.The newly formed mineralized callus area of rats in the vibration group was larger than that in the control group after 2 and 4 weeks of the treatment.At 8 weeks,rats in the vibration group presented significantly larger volume of matured callus and better mechanical properties than rats in the control group.Conclusion LMHFV enhances the healing of osteoporotic fracture.
