知识与财富的链接
以L-半胱氨酸盐酸盐与甲醛为起始原料,经缩合酯化得到噻唑烷-4-甲酸甲酯,再在二氧化锰作用下氧化合成噻唑-4-甲酸甲酯,水解得到噻唑-4-甲酸。氧化反应最佳反应条件为n（噻唑-4-甲酸甲酯）∶n（MnO2）=1∶23、MnO2活化温度为300℃、80℃反应48h。氧化反应收率为80.8%。
Methyl thiazolidine-4-carboxylate was synthesized from L-Cysteine hydrochloride and formaldehyde by condensation and esterification.Methyl thiazole-4-carboxylate was synthesized by oxidation reaction.Thiazole-4-carboxylic acid was achieved from hydrolysis reaction.The mole ratio of methyl thiazole-4-carboxylate to MnO2 was 1∶23,the activation temperature of MnO2 was 300 ℃,reaction for 48 h at 80 ℃.The yield of oxidation reaction was 80.8%.