知识与财富的链接
阿尔茨海默病(Alzheimer's disease,AD)是一个连续的病理生理过程,包括轻度认知障碍前期(pre-MCI)、轻度认知障碍期(mild cognitive impairment,MCI)和痴呆期．AD临床期病程不可逆转,因此,pre-MCI和MCI的早期发现和干预就成为延缓和逆转AD发生的重要环节．大量研究表明,2型糖尿病(T2DM)胰岛素抵抗是导致MCI和AD的独立危险因素,T2DM与AD及AD前期认知功能障碍有密切关系．本文重点综述2型糖尿病与MCI及AD之间的相关性,探讨2型糖尿病治疗对AD的发生进行有效干预的可能性,为AD早期发现和临床治疗提供新线索．
Alzheimers's disease (AD) is a continuous pathological physiology process, including pre- MCI(mild cognitive impairment, MCI), MCI and dementia. For the irreversible of the clinical course of AD, finding early and treat right in the stage of preMCI or MCI are very important for slowing down or even reverse the procession of AD. Research shows that type 2 diabetes mellitus (T2DM ) is an independent risk factor for MCI and AD . This manuscript is a brief review of current concepts in the mechanisms potentially linking T2DM with cognitive impairment.